Regardless of cellular heterogeneity, inherited down-regulation and/or absence of CKs and EpCAM [4, 59], as well as CTC size variation ranging from similar or smaller than WBCs up to large tumor cells [6, 10, 12], SE-iFISH® enables expeditious detection of CTCs, DTCs and CTMs in regard to efficient enrichment, identification and classification of hypotonic-free, heterogeneous subpopulations of non-hematopoietic heteroploid cancer cells. This evidence concerns the gene EPCAM and neoplasm.