CYBA and Hepatic fibrosis: We found increased ROS in the context of increased lipid peroxidation [which is known to increase in liver disease (31)] and greater expression of the NOX-2 components (Gp91phox, P22phox, P47phox, and P67phox), a major source of hepatic ROS production, which have been observed in hepatic fibrosis (32, 33).