In addition to the beta blockers carvedilol, metoprolol CR/XL, and bisoprolol, [96–99, 106] patients with hypertension, coronary artery disease, and congestive heart failure should be treated with diuretics and ACE inhibitors or angiotensin receptor blockers (ARBs [96–99, 106], and patients with persistent severe symptoms with aldosterone antagonists [96–99, 105–107]. This evidence concerns the gene ACE and Hypertension.