Information available via the tools listed suggest that multiple pathways are involved by miR-377-5p and miR-663b, affecting tumor suppressor functions (LATS2, TXNIP, wtKRAS, CDKN1A, PPM1A), cytoskeleton regulation (PAK1, PKN1) and a proinflammatory and reactive oxygen species adaptive response (TNF, IFNG, IL1B, HMOX1, SOD1 and SOD2). This evidence concerns the gene HMOX1 and neoplasm.