NPPB and chronic kidney disease: In patients with end-stage renal disease not confined to Fabry disease, a relationship between left atrial size and OSA severity has been described recently.32 In addition, left atrial size has been shown to be a predictor of CSA in a study on 62 non-Fabry patients with chronic heart failure.33 However, MSSI, NT-proBNP, and LAD did not remain statistically significant in the multivariable analysis.