Heidbreder et al. [25] conducted a study in rats subjected to insulin-dependent hypoglycemia or insulin-independent cytoglucopenia provoked by 2-deoxy-D-glucose (2-DG), and suggested that the hypoglycemia or cytoglucopenia were fully effective to cause a rapid increase of HIF-3αmRNA levels, whereas other HIFs remained unaffected. Here, INS is linked to Hypoglycemia.