In neurons, HSPA8 is known to be involved in the lysosomal degradation of α-synuclein, which accumulates in Parkinson's disease and other neurodegenerative diseases [96], and in the degradation of the amyotrophic lateral sclerosis-linked mutant SOD1 protein [97, 98]. The gene discussed is HSPA8; the disease is amyotrophic lateral sclerosis.