Genetic depletion of SOD1 is implicated in a murine model of AMD [99, 100], in which our group has very recently shown that anti-HSPA8 AAbs develop before overt AMD-like changes develop but at a stage when marked intraretinal inflammation is already present [New et al. Invest. Ophthalmol. Vis. Sci. 2015; 56: E-Abstract 3986]. This evidence concerns the gene HSPA8 and age-related macular degeneration.