MAGE-A9 depletion in SPCA-1-MAGE-A9 and NCI-H1975-MAGE-A9 cells contributed to an increased apoptotic response to various levels of chemotherapeutic reagents that are commonly used for lung cancer including GEM, DDP, Taxol and PEM (Figure 4B and 4C: P < 0.05, part data not shown). This evidence concerns the gene MAGEA9 and lung cancer.