[16] To date, numerous miRNAs have been documented to directly regulate autophagic signaling in certain cancer cell lines, including miR-130a (targets ATG2B and DICER1), [17] miR-376b (targets Beclin-1 and ATG4c), [18] miR-181a (targets ATG5) [19]. The gene discussed is BECN1; the disease is cancer.