Further studies showed that over-expression of UVRAG significantly increased the ratio of Bax/Bcl- 2 and the degradation of p62, suggesting that UVRAG promotes apoptosis and autophagy in colon cancer cells, and treatment of cells with 3-MA inhibited UVRAG-induced apoptosis and autophagy (Figure 4D). The gene discussed is BAX; the disease is malignant colon neoplasm.