Whereas transfection of the GBM cells with SRC or FAK siRNA led to respective 40% and 49% inhibition as compared to non-silenced cells under the microenvironment, targeted inhibition on ITGB3 achieved the most effective inhibition on cell invasion by 83% (Figures 2F, 4C and 4D). This evidence concerns the gene PTK2 and glioblastoma.