The data showed that, as compared to vector xenografts, –EGFRvIII tumors exhibited a greatly shortened survival (Figure 5A), characteristics of a more advanced tumor grade, including a higher tumor proliferation rate as shown by Ki-67 staining (Figure 5B), intensive angiogenesis with a great number of necrotic foci and aggressive tumor invasion to adjacent tissues (Figure 5C, 5D and Supplementary Figure S2B). Here, MKI67 is linked to neoplasm.