Our data emphasize that, conjugated function of tumor microenvironment, i.e. hypoxia, ECM, integrins and the mutant EGFR, makes an integrated unit for rapid tumor progression, where the intergin β3 comprises the best target, as the integrin is not only expressed in tumor cells, but also in activated endothelial cells during tumor angiogenesis [26]. The gene discussed is EGFR; the disease is neoplasm.