Table 3 shows the top 10 DEGs (FC ≥ 1.5) that were consistently appeared in these datasets. Average fold-change and lowest p-values have been indicated. Our study suggests that AD-lesions were associated with up-regulation of genes encoding serpins (SERPINB4, SERPINB3) and S100 proteins (S100A8 and S100A9) with beta-defensin, AKR1B10, CCL18 and epidermal protease inhibitor PI3. Here, S100A8 is linked to Alzheimer disease.