When we compared chronic lesional AD samples from all the datasets with the control sample data, the top 10 up-regulared genes found were SERPINB, AKR1B10, S100A9, LTF, SERPINB3, RRM2, MMP12, FOXM1, S100A8 and CCL22, while the top down-regulated genes included CORIN, LOR and microsenoprotein. The gene discussed is LORICRIN; the disease is Alzheimer disease.