CACNA1A and spinocerebellar ataxia type 6: Besides, A454T mutation (located at the first intracellular loop connecting domains I and II of α1A) has been linked to a heterogeneous ataxic disorder with clinical features midway between EA2 and spinocerebellar ataxia type 6 (SCA6, other allelic disorder associated with mutations in the CACNA1A gene) [32].