CACNA1A and familial or sporadic hemiplegic migraine: In an attempt to understand how a CACNA1A HM mutation can also lead to such severe clinical phenotype, the deletion of a highly conserved phenylalanine located at the S6 pore region of α1A domain III (ΔF1502), found in a case of congenital ataxia and hemiplegic migraine, has recently been functionally characterized [44].