In view of the likelihood of CCR8 expression on tumor cells as it was reported to trigger tumor cells migration or invasion through lymphatic vasculature, and the open data from The Cancer Genome Atlas that CCR8 mRNA are unregulated in 16% ccRCC cases (61 of 392), we hypothesized that intratumoral overexpression of CCR8 may serve as a potential prognosticator of ccRCC recurrence. Here, CCR8 is linked to nonpapillary renal cell carcinoma.