CCR8 and nonpapillary renal cell carcinoma: It should be acknowledged that this study lack independent external validation, and it seem likely that the study design of retrospectively analyzing post-nephrectomy tumor samples, particularly with the intratumoral heterogeneity of regimens, would hinder the robustness of predictive biomarkers, further experimental studies are also required to identify the detailed role of CCR8 in ccRCC.