EBV latent membrane protein-1 and -2 (LMP1 and 2) have been confirmed to promote progression and metastasis of NPC [54, 55], but the positive rate of EBV-LMP expression in NPC is only 61% [56], it don't clearly explain NPC high metastasis. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.