Several target genes regulated by miR-215 in different cancers have been reported [10, 20–22], and we observed that RUNX1 is a direct target of miR-215 as evidenced by the fact that ectopic expression of miR-215 reduced luciferase activity of the RUNX1 promoter and miR-215 downregulated RUNX1 expression (Figure 4). Here, RUNX1 is linked to cancer.