Unless CAC is detected early, patients have rather poor prognosis and show resistance to cancer therapeutics [7], which can be explained by the facts that cancer stem cell (CSC) foci still persist in inflamed colon tissue even after the removal of cancer tissues and the possible presence of other target implicated in oncogenic inflammatory mediators such as IL-6, regenerating gene-l alpha (REG-1α), etc beyond current targeting TNF-α [8]. This evidence concerns the gene TNF and cancer.