Since IBD have clinical features of chronic relapsing inflammation, several proinflammatory cytokines such as TNF-α, IL-6, and IL-1β can induce mutagenic environments such as increased levels of intracellular reactive oxygen species and reactive nitrogen species, which induce DNA damage as well as epigenetic changes that silence tumor suppressors and promote tumor initiation [4–6]. The gene discussed is IL6; the disease is inflammatory bowel disease.