H7 treatment also induced cell differentiation in U937 (Figure 5B, 5C, Supplementary Figure S3A), in HL60 (Figure 5D, 5E, Supplementary Figure S3B), in some primary leukemia cells (Figure 5F, 5G, Table 1, Supplementary Figure S3C, 3D, 3E), and slightly in CBMNCs and BMMNCs (Table 1, Supplementary Figure S3F, 3G), as shown by the increased CD11b and CD14 expression and/or by the morphological changes in cells. The gene discussed is ITGAM; the disease is leukemia.