However, the results for GPR39 expression correlated with the dedifferentiation of the tumor, with increased expression from WD (1.22 a.u. ± 0.2), MD (1.60 a.u. ± 0.2), to PD (2.44 a.u. ± 0.2) (Figure 5D: WD/PD, **P < 0.01; and MD/PD, **P < 0.01; Figure 5D). This evidence concerns the gene GPR39 and neoplasm.