ADM cells showed a bivalent state with similar levels of H3K4me3 and H3K27me3, whereas tumor cells exhibited an enrichment of H3K27me3 at the Ptf1a and Rbpjl promoter and a slightly elevated H3K4me3 modification at the Rbpj promoter (Figure 3A). The gene discussed is PTF1A; the disease is neoplasm.