ADM cells showed a bivalent stage of H3K4me3 and H3K27me3 on the Ptf1a, Rbpj and Rbpjl promoter, which might explain their plasticity towards acinar cell redifferentiation in pancreatitis-driven regeneration or towards tumor cell dedifferentiation in the presence of oncogenic Kras. This evidence concerns the gene KRAS and pancreatitis.