In 13 identified cluster-related signatures, TP53, CTNNB1, PIK3CA, ARID1A, FBXW7, and PPP2R1A (which accounted for 65.0% (13/20) of eSNVs) are well-established recurrently mutated genes in endometrial cancers [5]. The gene discussed is PPP2R1A; the disease is endometrial cancer.