More interestingly, FZD7 was up-regulated by BMSCs, and BMSCs from CML patients showed increased efficiency to up-regulate the expression of FZD7 along with increment of β-catenin and Wnt target molecules such as MDR1, c-Myc, and CD44 in CML cells. Here, FZD7 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.