VDAC1 and cancer: We also silenced the VDAC1 gene in SiHa and CaSki cancer cells to examine the influence of VDAC1 on cisplatin cytotoxicity, and found that when the VDAC1 gene had been silenced, the cell cytotoxicity of cisplatin was significantly enhanced at different concentrations of cisplatin (Figure 6E and 6F).