VDAC1 and neoplasm: In addition, methyl jasmonate, the plant stress hormone of the jasmonate family and clotrimazole have been shown to bind to hexokinase, which protects against cell death via interactions with VDAC1, and to detach it from mitochondria thus interfering with hexokinase binding to VDAC leading to an anti-tumor effect in several cancer cell types [22–24].