The results showed that cancer tissues with positive VDAC1 immunoreactivity exhibited deep stromal invasion (>10 mm in depth of stromal invasion, p<0.001, OR: 4.14 and 95% CI: 1.80-9.88) and large tumor size (>4 cm in diameter, p=0.001, OR: 3.77 and 95% CI: 1.60-9.00, Table 2). The gene discussed is VDAC1; the disease is cancer.