SPHK1 and ovarian cancer: Evaluation of SPHK1 expression in different laser-microdissected ovarian tissue components (GSE40595) showed that CAFs expressed significantly higher levels of SPHK1 than ovarian cancer cells (p=0.0002) or normal ovarian surface epithelium (OSE, p=0.0003) (Figure 2E and Supplementary Figure S3).