Transcript levels of ACTA2 (the gene encoding αSMA) and FAP were significantly higher in SPHK1-High tumors than in SPHK1-Low tumors in both the AOCS and TCGA datasets (Figure 2D and Supplementary Figure S2B), suggesting that SPHK1 could be associated with an increased abundance of CAFs in ovarian tumors. Here, SPHK1 is linked to ovarian neoplasm.