AKT1 and ovarian carcinoma: To explore the effect of POSTN treatment on platinum sensitivity in A2780 epithelial ovarian cancer cells, we treated the A2780 cell line in 4 groups: (1) control group (2) POSTN group with recombinant POSTN protein (1 μg/ml) in cultured medium for 24 hours (3) AKT inhibitor group with MK-2206(1 μg/ml) for 2 hours (4) combined group with recombinant POSTN protein (1 μg/ml) in cultured medium for 24 hours followed bv AKT inhibitor groups with MK-2206(1 μg/ml) for 2 hours.