The rescue of BRCA-1 and ERα by αNF in UACC-3199 breast cancer cells were biological changes associated with preferential induction of CYP1A1. Conversely, αNF did not affect ERα levels, but antagonized E2-dependent activation of BRCA expression, in ERα-positive MCF-7 cells. The gene discussed is CYP1A1; the disease is breast cancer.