NPM1 and leukemia: On the other hand, Q‐PCR on target genes is easy, highly standardized and relatively cheap, but it is applicable mainly in AML patients with known molecular aberrations (e.g., molecular rearrangements arising from chromosomal translocations such as in CBF leukemias, or gene mutations such as NPM1 and Flt3‐ITD), which are observed in a minority of cases 29, 30, 31.