KLK3 and Familial prostate cancer: Similarly, there was no significant difference between the two age groups in Gleason score >6 (X2 = 2.3, p = 0.13), Gleason score >7 (X2 = 1.2, p = 0.27), Gleason score as a continuous variable (t = −1.530, p = 0.13, mean difference = −0.195, 95 % CI of difference = −0.45 to 0.06), high-risk prostate cancer features (X2 = 0.007, p = 0.93) or pre-biopsy PSA scores (t = 0.977, p = 0.33, mean difference = 1.45, 95 % CI of difference = −1.50 to 4.41).