MUS81 and hepatocellular carcinoma: However, in the HepG2shMus81 and Bel‐7402shMus81, cells underwent EPI treatment and the percentages at S phase were dramatically increased to 88.97 and 69.69% with a obvious decrease in the percentages at G1 phase, indicating that Mus81 knockdown induces a significant S‐phase arrest in HCC cells under EPI treatment.