MUS81 and hepatocellular carcinoma: To further evaluate the implication of Mus81 knockdown on HCC chemosensitivity in vivo, an HCC chemotherapy mouse model was therefore established by combining subcutaneously injection of HCC cells (HepG2, HepG2shCtrl, and HepG2shMus81 cells) with subsequent intraperitoneally injection of chemotherapeutic drugs (EPI and 5‐FU).