On the contrary, RasGRP3 gene expression level increased two-fold in PBMCs from RA patients (Fig. 1b) and six-fold in B cells from HC after 48 hours of culture with TNFα (Figs. 4a and 5b), leading us to conclude that RasGRP3 in B cells was modulated by TNFα. The gene discussed is RASGRP3; the disease is rheumatoid arthritis.