Overall, this proof-of-concept study is quite unique as it has coupled PSMA-based SPECT/CT images to the growth of DPC-1 prostatic tumors and metastases both local and distant, then histopathologically confirmed and showed to express the targeted PSMA/antigen in a time-wise manner resembling the natural history of prostate cancer. Here, FOLH1 is linked to prostate neoplasm.