Furthermore, temsirolimus and everolimus, inhibitors of the mammalian target of rapamycin (mTOR) which block the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway involved in diverse cellular functions including cell proliferation, survival and angiogenesis, have been found to be effective agents against advanced RCC in clinical settings [12,13]. Here, MTOR is linked to renal cell carcinoma.