While there was no detectable hnRNP K expression in the cytoplasmic component of RPTEC (normal renal cells), ACHN and 786–0 RCC cells, both A498 and Caki-1 RCC cells showed weak positive signals in the cytoplasmic fraction compared with the nuclear fraction (Fig 4A). This evidence concerns the gene HNRNPK and renal cell carcinoma.