Also in RCC cells, we elucidated that MMP-2 expression was down-regulated by endogenous hnRNP K knock-down, and exogenous hnRNP K dominantly expressed in the cytoplasm reversed the inhibition of MMP-2 expression by endogenous hnRNP K knock-down (Fig 6E). The gene discussed is HNRNPK; the disease is renal cell carcinoma.