OPTN and open-angle glaucoma: To date, several causative genes and 16 POAG-associated loci have been identified, including myocilin (MYOC/GLC1A; MIM 601652) [7, 8], optineurin (OPTN/GLC1E; MIM 137760) [9], WD repeat domain 36 (WDR36/GLC1G; MIM 609669) [10, 6], cytochrome P450 1B1 (CYP1B1; MIM 231300) [11,12].