HIF1A and neoplasm: Tumor and mesodermal adult stem cell studies have elucidated several mechanisms on how physioxia would alter activation of cellular pathways (Eliasson & Jonsson, 2010; Erler et al., 2004; Forristal et al., 2013b; Jang & Sharkis, 2007; Kubota, Takubo & Suda, 2008; Rosova et al., 2008; Song et al., 2006), such as the hypoxia-inducible factor 1 alpha mechanism.