Homotaurine protects neurons both “in vitro”(NGF-differentiated PC12 cells and primary cortical neurons) and “in vivo” (in rats subjected to the intraluminal filament model of MCAO: Middle cerebral artery occlusion) against ischemic stroke, through disruption of the interaction between PSD95 and nNOS and inhibition of nNOS translocation [76]. Here, NOS1 is linked to ischemic stroke.