VEGFA and Renal insufficiency: Renal failure was accompanied by a compensatory renal hypertrophy and angiogenesis in the CRF rats, as revealed by the increase in KW/BW and serum VEGF levels; a high HW/BW ratio was also found in the CRF group, which might be caused by the supplementary effort of the left ventricle muscle to pump blood in this condition of anemia secondary to renal failure development (Table 1).