TNF and rheumatoid arthritis: A recent randomized controlled trial in rheumatoid arthritis (RA) patients determined that a strategy of first adding two Disease-modifying Antirheumatic Drugs (DMARDs) to methotrexate (a combination known as Triple Therapy) is neither inferior nor less safe than first adding the biologic anti-TNF drug etanercept to methotrexate in patients with active disease despite the methotrexate [1].