To provide further insight on the role of immunosenescence during cancer, variations in subpopulations of CD8+ T-cells, including the senescent CD28+CD57+ and CD28-CD57+ cells [1, 3], were followed in patients with different cancers affecting the lungs (stages III and IV) , receiving chemotherapy, over a period of 6 months. The gene discussed is B3GAT1; the disease is cancer.