For head and neck squamous cell carcinoma (HNSCC), the knowledge on FGFR3 protein expression is yet limited, while such novel therapeutic targets are highly awaited for disseminated or recurrent HNSCC because current treatment regimens are often ineffective and overall survival rates have remained poor over the past two decades 7, 8. Here, FGFR3 is linked to head and neck squamous cell carcinoma.