The minor breaking patterns are found in about 10% of ETV6‐RUNX1‐positive ALL and breaks within ETV6 intron 5 and RUNX1 intron 2 or 3, generating ETV6 intron 5‐RUNX1 intron 2/3 rearrangement 42, 43, 44. Here, RUNX1 is linked to acute lymphoblastic leukemia.