However, Hoskins et al. [14] and Hu et al. [15] reported inconsistent results from meta-analyses of the relationship between homozygosity for UGT1A1*28 and neutropenia in patients treated with CPT-11 at a starting dose of <150 mg/m2, and no definitive relationship was therefore demonstrated. Here, UGT1A1 is linked to Decreased total neutrophil count.