MTDH and hepatocellular carcinoma: The AEG-1 gene is an oncogene, which is located at chromosome 8q22 [5], and it is observed that elevated expression of AEG-1 promoted tumor proliferation, progression or metastasis in multiple carcinomas such as EC [6], HCC [7], neuroblastoma [8], breast cancer [9], prostate cancer [10] and malignant glioma [11].