Blocking Hh-signaling using the plant secondary metabolite cyclopamine (or RNA interference of Gli) suppresses proliferation of several human prostate cancer cell lines [11]; however, cyclopamine’s potent inhibitory effect is not therapeutically favorable, because of its rapid clearance, non-specific toxicity and instability as well as off-target effects at high concentrations [3,12]. The gene discussed is GLI1; the disease is prostate cancer.