Hsd11b1 is present in PC3 and LnCaP human prostate cancer cells, and the HSD11B1’s 11-dehydrogenase activity is preserved while the 11-reductase activity is not [35,36], indicating HSD11B1 is important for maintaining the concentration of glucocorticoid in prostate and prostate cancer cells. This evidence concerns the gene HSD11B1 and Familial prostate cancer.