However, while the current study demonstrated that HER2 inhibition significantly increases ERβ expression in cells exposed to obesity-associated circulating factors, supporting the conclusion that HER2 mediates the obesity-ERβ link, we also showed that HER2 inhibition non-significantly increases ERβ expression in cells exposed to N sera. The gene discussed is ERBB2; the disease is obesity due to melanocortin 4 receptor deficiency.