B3GNT3 is likely to be the most probable candidate involved in the biosynthesis of the backbone structure of dimeric sialyl Lewis A (Galβ1–3GlcNAcβ1–3Galβ1–3GlcNAc), which is a cancer associated glycosphingolipid antigen in human colon cancer tissues and the colon cancer cell line Colo205 [19]. Here, B3GNT3 is linked to malignant colon neoplasm.