BRAF and malignant colon neoplasm: However, the genomic areas included in this panel are well known to play critical roles in carcinogenesis, with genes frequently mutated in various malignancies such as APC in colon cancer [20], BRAF in melanoma or hairy cell leukemia [21], EGFR in non-small cell lung cancer, and IDH1 in glioblastoma multiforme [22] to name a few.