Other chromatin remodeling proteins associated with this silencing complex have been implicated in memory impairment, including histone deacetylase 2 (HDAC2) [89], [90] and methyl CpG binding protein 2 (MeCP2) which is mutated in Rett syndrome resulting in NRSF/coREST-mediated repression of BDNF expression [91]. The gene discussed is REST; the disease is memory impairment.