PANK2 and neurodegeneration with brain iron accumulation: Neuronally-derived eosinophilic spheroid bodies, thought to represent degenerating neurons and accumulation of protein and lipid storage material as well as damaged organelles (e.g. mitochondria and vesicles), are a pathologic hallmark of several NBIA disorders, including those caused by mutations in PANK2 and C19orf12 (Kruer, 2013) — genes that belong to a co-expression module that reflects neuronal signatures.