This is the case for genes associated with Mucolipidosis type IV (MCOLN1-OMIM# 605248), X-linked sideroblastic anemia with ataxia (ABCB7-OMIM#300135), Parkinson's disease (VPS35-OMIM#601501, and SYNJ1-OMIM#604297), Alzheimer's disease (ADAM10-OMIM#602192, and PLD3-OMIM#615698), and amyotrophic lateral sclerosis (UBQLN2-OMIM#300264, VCP-OMIM#601023, SIGMAR1-OMIM#601978, and SOD1-OMIM#147450). Here, VPS35 is linked to early-onset autosomal dominant Alzheimer disease.