ICAM-1, a member of the immunoglobulin superfamily expressed by the endothelial cells, fostering the adhesion of the leukocytes to the endothelium, has also been targeted using anti-ICAM-1 functionalized MPIO, which showed sufficient sensitivity to image neuroinflammation in a MCAO stroke model in vivo [39] and after radiation injury [40]. Here, ICAM1 is linked to stroke disorder.