Activated AMPK could abolish inflammation through the MAPKs signaling pathway; activated AMPK could attenuate insulin resistance by phosphorylating IRS-1, AKT and dephosphorylate ERK, JNK and NF-κB; it also suppresses fatty acid synthesis, gluconeogenesis and increases mitochondrial β-oxidation [101]. Here, IRS1 is linked to Insulin resistance.