NES and neoplasm: Endoxifen-induced tumours expressed GFAP, nestin, Sox2, Olig2, PDGFRa and doublecortin (Fig. 5E1-J1), and were indistinguishable from tumours generated by Adeno-Cre or Adeno-GFAP-Cre injection, as described previously (Henriquez et al., 2013; Jacques et al., 2010) and as shown in Fig. 5E2-J3.