PTEN and glioma: We have previously shown that Adeno-Cre- or Adeno-GFAP-Cre-induced recombination of the tumour suppressor genes Pten and p53 in stem/progenitor cells of the SVZ gives rise to glial tumours, with histological features of oligodendroglial and astrocytic tumours (Henriquez et al., 2013).